Association between early changes of left atrial volume and right ventricular function after transcatheter edge-to-edge repair for mitral regurgitation

Abstract Funding Acknowledgements Type of funding sources: None. Background Transcatheter edge-to-edge repair (TEER) has recently become a therapeutic option for patients with severe mitral regurgitation (MR) who are unsuitable surgery, in order to improve clinical outcomes. MR is determinant structural and functional changes all cardiac chambers. The left atrium (LA) the right ventricle (RV) play an important role pathogenesis symptoms affected by MR. Recent data suggests that reverse (LV), as well LA RV, associated reduced morbidity mortality. Purpose aim study test association between LAV RV function early after TEER. Methods This retrospective enrolled chronic MR, at high surgical risk, underwent TEER February 2015 July 2022. We evaluated baseline before discharge their relation symptoms. Results A total 52 were included (mean age 65.2 ± 10.2 years; 69% males, mean ventricular ejection fraction [LVEF] 28.8 5.7%). No differences echocardiographic characteristics detected groups had volume (LAV) reduction (n = 31) those did not 21), including assessed New York Heart Association (NYHA) classification. However, former group significant higher size (LAVI 76.6 18.2 vs. 61.2 17.6 mL/m2, p 0.004). In overall population, we observed increase tricuspid annular plane systolic excursion (TAPSE), S’ wave Tissue Doppler ratio TAPSE pulmonary artery pressure (TAPSE/PASP), decrease PASP (respectively, 0.034, 0.003, < 0.001 0.001). Compared have reduction, showed TAPSE/PASP (from 0.40 0.17 0.52 0.21 mm/mmHg, 0.002), 8.7 1.6 9.4 1.7 cm/s, 0.005) 50.3 14.3 38.9 11.5 mmHg, absolute change from was (b coefficient 0.55, 95% confidence interval 0.09, 1.02, 0.022) −4.06, −7.78, −0.33, 0.033), even adjustment covariates b 0.61, 0.07, 1.14, 0.027 −4.82, −9.43, −0.23, 0.040). Finally, NYHA class significantly improved whose (p 0.011). Conclusion this study, structure parameters been described. After TEER, improved, especially reduction. latter, improvement class.